{"id":94665,"date":"2025-05-31T12:12:06","date_gmt":"2025-05-31T12:12:06","guid":{"rendered":"https:\/\/pakistaninewspaperlist.com\/news\/new-data-show-roches-itovebi-significantly-extended-survival-in-a-certain-type-of-hr-positive-advanced-breast-cancer\/"},"modified":"2025-05-31T12:12:06","modified_gmt":"2025-05-31T12:12:06","slug":"new-data-show-roches-itovebi-significantly-extended-survival-in-a-certain-type-of-hr-positive-advanced-breast-cancer","status":"publish","type":"post","link":"https:\/\/pakistaninewspaperlist.com\/news\/new-data-show-roches-itovebi-significantly-extended-survival-in-a-certain-type-of-hr-positive-advanced-breast-cancer\/","title":{"rendered":"New data show Roche\u2019s Itovebi significantly extended survival in a certain type of HR-positive advanced breast cancer"},"content":{"rendered":"<div id=\"main-body-container\" itemprop=\"articleBody\">\n<ul>\n<li style=\"margin-top:0cm; margin-bottom:10pt;\"><strong>The Itovebi<sup>TM<\/sup> (inavolisib)-based regimen reduced the risk of death by more than 30% in people with <em>PIK3CA<\/em>-mutated HR-positive, HER2-negative advanced breast cancer, compared with palbociclib and fulvestrant alone<sup>1<\/sup><\/strong><\/li>\n<li style=\"margin-top:0cm; margin-bottom:10pt;\"><strong>The <em>PIK3CA<\/em> mutation is found in approximately 40% of HR-positive advanced breast cancers and is associated with a poor prognosis<sup>2,3<\/sup><\/strong><\/li>\n<li style=\"margin-top:0cm; margin-bottom:10pt;\"><strong>New data are being presented in an oral session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting and published in the <em>New England Journal of Medicine<\/em><sup>1<\/sup><\/strong><\/li>\n<\/ul>\n<p>Basel, 31 May 2025 &#8211; Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today positive final results from the overall survival (OS) analysis of the phase III INAVO120 study. These data showed Itovebi<sup>TM<\/sup> (inavolisib), in combination with palbociclib (Ibrance\u00ae) and fulvestrant, reduced the risk of death by more than 30% compared with palbociclib and fulvestrant alone. This represents a statistically significant and clinically meaningful improvement in overall survival for people with <em>PIK3CA<\/em>-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, endocrine-resistant, locally advanced or metastatic breast cancer.<sup>1<\/sup> The results are being presented in an oral session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting and simultaneously published in the<em> New England Journal of Medicine (NEJM).<\/em><sup>1<\/sup><\/p>\n<p>&#8220;For the first time, a PI3K pathway-targeted drug has shown it can help people with this breast cancer subtype live longer,&#8221; said Levi Garraway, M.D., Ph.D., Roche\u2019s Chief Medical Officer and Head of Global Product Development. &#8220;Itovebi exemplifies our continued commitment to improve survival rates for people with this common<em> PIK3CA<\/em> mutation, for whom more effective treatment options are needed.\u201d<\/p>\n<p>\u201cThe landmark data for the inavolisib-based regimen showed not only a doubling in progression-free survival, but importantly that it extended lives and gave people more time without chemotherapy,\u201d said Professor Nicholas Turner, Lead Study Author and Professor of Molecular Oncology at The Institute of Cancer Research, and Consultant Medical Oncologist at The Royal Marsden NHS Foundation Trust, London, United Kingdom. \u201cThese results give us confidence that this regimen could become the new standard of care in the first-line setting, having demonstrated a substantial benefit on patient outcomes and quality of life.\u201d<\/p>\n<p>The Itovebi-based regimen demonstrated a meaningful OS benefit compared with palbociclib and fulvestrant alone.<sup>1<\/sup> The median OS was 34.0 months (95% CI: 28.4\u201344.8) for people in the Itovebi arm, compared with 27.0 months (95% CI: 22.8\u201338.7) in the palbociclib and fulvestrant arm (stratified hazard ratio [HR]=0.67; 95% CI: 0.48\u20130.94, p-value=0.0190 [boundary=0.0469]).<sup>1<\/sup> The benefit seen in delaying cancer progression was maintained in the updated analysis, with the Itovebi-based regimen showing a consistent improvement in median progression free survival of 17.2 months versus 7.3 months (stratified HR=0.42; 95% CI: 0.32-0.55) in the comparator arm.<sup>1<\/sup> <\/p>\n<p>The Itovebi-based regimen also led to a statistically significant improvement in objective response rate (the percentage of patients whose signs of cancer completely disappear or their tumours shrink significantly after treatment) and ad-hoc exploratory analyses showed it substantially delayed time to chemotherapy by approximately two years (stratified HR=0.43; 95% CI: 0.30-0.60).<sup>1<\/sup> No new safety signals were observed at the time of the final OS analysis, with a low discontinuation due to adverse events supporting good tolerability.<sup>1<\/sup><\/p>\n<p>The Itovebi-based regimen is approved in the United States, Switzerland, Canada, Australia, United Arab Emirates and China. In May, it received a positive opinion from the European Medicines Agency\u2019s Committee for Medicinal Products for Human Use (CHMP), with a final decision regarding the approval expected from the European Commission in the near future. Data from the INAVO120 study are currently under review with other global health authorities.<\/p>\n<p>Beyond INAVO120, Itovebi is currently being investigated in three company-sponsored phase III studies (INAVO121, INAVO122, INAVO123), all in <em>PIK3CA<\/em>-mutated, locally advanced or metastatic breast cancer in various combinations.<sup>4-7<\/sup> We are exploring additional studies in breast cancer and other tumour types with the hope of providing the benefit of this targeted therapy to more people with <em>PIK3CA<\/em> mutations. <\/p>\n<p><strong>About Itovebi <sup>TM<\/sup> (inavolisib)<br \/><\/strong>Itovebi is an oral, targeted treatment that has been shown to provide well-tolerated and durable disease control in people with <em>PIK3CA<\/em>-mutated, hormone receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer, who often have a poor prognosis and are in urgent need of new treatment options.<sup>2,3,8<\/sup> Itovebi has been designed to help minimise the overall burden and toxicity of treatment and is differentiated from other PI3K inhibitors due to its high potency and specificity for the PI3K alpha isoform versus other isoforms, and unique mechanism of action that facilitates the degradation of mutated PI3K alpha.<sup>9,10<\/sup><\/p>\n<p><strong>About the INAVO120 study<\/strong><br \/>The INAVO120 study [<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=iP-lgcLwDIh1lbiX9TDd75jsA4SZmBbq3RQCy9Hs8g6Pi_G-uxwRELeY-OPj-3z-4CY0h4nQp1wBG4IlqfOxbxTS6DBcFg0DuUZkYjaMv5PJLjc073HzYIr9OIaBsIFW\" rel=\"nofollow\" target=\"_blank\" title=\"NCT04191499\">NCT04191499<\/a>] is a phase III, randomised, double-blind, placebo-controlled study evaluating the efficacy and safety of Itovebi\u2122 (inavolisib) in combination with palbociclib and fulvestrant versus placebo plus palbociclib and fulvestrant in people with <em>PIK3CA<\/em>-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer whose disease progressed during treatment or within 12 months of completing adjuvant endocrine therapy and who have not received prior systemic therapy for metastatic disease.<sup>4<\/sup><\/p>\n<p>The study included 325 patients, who were randomly assigned to either the investigational or control treatment arm.<sup>4<\/sup> The primary endpoint is progression-free survival, as assessed by investigators, defined as the time from randomisation in the clinical trial to the time when the disease progresses, or a patient dies from any cause.<sup>4<\/sup> Secondary endpoints include overall survival, objective response rate, and clinical benefit rate.<sup>4<\/sup><\/p>\n<p>Beyond INAVO120, Itovebi is currently being investigated in three additional company-sponsored phase III clinical studies in<em> PIK3CA<\/em>-mutated locally advanced or metastatic breast cancer in various combinations:<sup>5-7<\/sup><\/p>\n<ul>\n<li style=\"margin-top:0cm; margin-bottom:0cm;\">in combination with fulvestrant versus alpelisib plus fulvestrant in HR-positive\/HER2-negative breast cancer post cyclin-dependent kinase 4\/6 (CDK4\/6) inhibitor and endocrine combination therapy (INAVO121; NCT05646862).<\/li>\n<li style=\"margin-top:0cm; margin-bottom:0cm;\">in combination with pertuzumab plus trastuzumab for subcutaneous injection (SC) versus pertuzumab plus trastuzumab for SC and optional physician&#8217;s choice of endocrine therapy as a maintenance treatment in HER2-positive disease (INAVO122; NCT05894239).<\/li>\n<li style=\"margin-top:0cm; margin-bottom:0cm;\">in combination with CDK4\/6 inhibitor and letrozole versus placebo plus a CDK4\/6 inhibitor and letrozole in the first-line setting in <em>PIK3CA<\/em>-mutated HR-positive\/HER2-negative, endocrine-sensitive breast cancer (INAVO123; NCT06790693).\u00a0<\/li>\n<\/ul>\n<p><strong>About hormone receptor (HR)-positive breast cancer<br \/><\/strong>HR-positive breast cancer is the most prevalent type of all breast cancers, accounting for approximately 70% of cases.<sup>11,12<\/sup> A defining feature of HR-positive breast cancer is that its tumour cells have receptors that attach to one or both hormones \u2013 oestrogen or progesterone \u2013 which can contribute to tumour growth. People diagnosed with HR-positive metastatic breast cancer often face the risk of disease progression and treatment side effects, creating a need for additional treatment options.<sup>12-14<\/sup> The PI3K signalling pathway is commonly dysregulated in HR-positive breast cancer, often due to activating <em>PIK3CA <\/em>mutations, which have been identified as a potential mechanism of intrinsic resistance to standard of care endocrine therapy in combination with cyclin-dependent kinase 4\/6 inhibitors.<sup>3<\/sup><\/p>\n<p><strong>About Roche in breast cancer<br \/><\/strong>Roche has been advancing breast cancer research for more than 30 years with the goal of helping as many people with the disease as possible. Our medicines, along with companion<\/p>\n<p>diagnostic tests, have contributed to bringing breakthrough outcomes in human epidermal growth factor 2-positive and triple-negative breast cancers. As our understanding of breast cancer biology rapidly improves, we are working to identify new biomarkers and approaches to treatment for other subtypes of the disease, including oestrogen receptor-positive breast cancer, which is a form of hormone receptor-positive breast cancer, the most prevalent type of all breast cancers.<sup>11,12<\/sup><\/p>\n<p><strong>About Roche<\/strong> <br \/>Founded in 1896 in Basel, Switzerland, as one of the first industrial manufacturers of branded medicines, Roche has grown into the world\u2019s largest biotechnology company and the global leader in in-vitro diagnostics. The company pursues scientific excellence to discover and develop medicines and diagnostics for improving and saving the lives of people around the world. We are a pioneer in personalised healthcare and want to further transform how healthcare is delivered to have an even greater impact. To provide the best care for each person we partner with many stakeholders and combine our strengths in Diagnostics and Pharma with data insights from the clinical practice.<\/p>\n<p>For over 125 years, sustainability has been an integral part of Roche\u2019s business. As a science-driven company, our greatest contribution to society is developing innovative medicines and diagnostics that help people live healthier lives. Roche is committed to the Science Based Targets initiative and the Sustainable Markets Initiative to achieve net zero by 2045.<\/p>\n<p>Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan.<\/p>\n<p>For more information, please visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=AMAYd8D-8tSrDbTde9l5XKhKmT4oy5Dr9OyuM7Do-gOk0CHkpdvVfD5UkbQnb1GfehhhaT3Isdfhzz1o4G2MEdZwnJvbUagEwOt03EM7Tp9MDQGBSoItUx-LjTEgswNUmOUFE2rI11Mh9-E361O0AscV4HJd_454GsiJ1gBGeyTkbkrBMW7k9_qpH9r6sCxAVz5Twimv_BnXxl1OOgPaYv5SjNeeQfuDeiCDMC-iwX0=\" rel=\"nofollow\" target=\"_blank\" title=\"www.roche.com\">www.roche.com<\/a>.<\/p>\n<p>All trademarks used or mentioned in this release are protected by law.<\/p>\n<p><strong>References<br \/><\/strong>[1] Turner NC, et al. INAVO120 Phase III trial final overall survival (OS) analysis of first-line inavolisib (INAVO)\/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV) in patients (pts) with <em>PIK3CA<\/em>-mutated, hormone receptor-positive (HR+), HER2-negative (HER2\u2013), endocrine-resistant advanced breast cancer (aBC). Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, 2025 May 30-June 03; Chicago, USA. Abstract #1003.<br \/>[2] Fillbrunn M, et al. <em>PIK3CA<\/em> mutation status, progression and survival in advanced HR+\/HER2- breast cancer: a meta-analysis of published clinical trials. BMC Cancer. 2022;22(1):1002.<br \/>[3] Anderson E, et al. A Systematic Review of the Prevalence and Diagnostic Workup of <em>PIK3CA <\/em>Mutations in HR+\/HER2\u2013 Metastatic Breast Cancer. Int J Breast Cancer. 2020;2020:3759179.<br \/>[4] ClinicalTrials.gov. A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Patients With <em>PIK3CA<\/em>-Mutant, Hormone Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer (INAVO120) [Internet; cited 2025 May]. Available from: \u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pyTPcqPv43fzbQVTKw28tqeloDsGxnjBl1gNaSAWYNaGjDlqAl9-ZHPjksxY5UgOWJORFGnjQbx3nhOlfezQb7C6DeS4XTbOKVcEt3g5qLMykd1aU82hXjXHzZ5oleXTNHb6mDJW-t1VNWpfLp4uvVgA-fcwp-X4Md0Sr8lFSBBJu4Cyr4ZNaiyASf7nsqEa\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04191499<\/a>.\u00a0<br \/>[5] ClinicalTrials.gov. A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative,<em> PIK3CA<\/em> Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4\/6i and Endocrine Combination Therapy (INAVO121) [Internet; cited 2025 May]. Available from: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pyTPcqPv43fzbQVTKw28tqeloDsGxnjBl1gNaSAWYNaGjDlqAl9-ZHPjksxY5UgO29hCOwSFtvk5v4utejb7qMTWOHGRuskUhNi6-fu-X6VkQRVr_3zFirp-6eT2eJ8Ker3HmMqatiuN59RCuEoXc0bOZCQBvd4e9iPHjkfsn2VYX2utXtJ_qMGrvQZ-3VIk\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05646862<\/a>.\u00a0<br \/>[6] ClinicalTrials.gov. A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With <em>PIK3CA<\/em>-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer (INAVO122) [Internet; cited 2025 May]. Available from: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pyTPcqPv43fzbQVTKw28tqeloDsGxnjBl1gNaSAWYNaGjDlqAl9-ZHPjksxY5UgOYpn_mjJ31zeWRVl71PHLQn7Ibthu5DxTuHgrcZzi4m1cOAOvD7wl1h_jOGIVuL6SbbNRdE1nUp0eHVD7_o6gjJ8KZsQpmREwy4LU9GVBHxUEfFQ0L5erh5_s9CIg8kLs\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05894239<\/a>.\u00a0<br \/>[7] ClinicalTrials.gov. A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4\/\u200b6 Inhibitor and Letrozole vs Placebo + CDK4\/\u200b6i and Letrozole in Participants With Endocrine-Sensitive <em>PIK3CA<\/em>-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer (INAVO123) [Internet; cited 2025 May]. Available from: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pyTPcqPv43fzbQVTKw28toTeTeaYPFzfNvbzaauNrM67yE-9F-HBEoD-4xhlHogiOcdv-AxM3zVy7s5fYUiYuxfS9MBtPIuJYo-6cDqh8GpdpUp9j_mpn2G9Voj2AfySnQC3lBuP2x2yMervH5Z70RHGGVu6uZA_cFhATpP-ql0=\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/clinicaltrials.gov\/study\/NCT06790693<\/a>.<br \/>[8] Turner NC, et al. Inavolisib-Based Therapy in <em>PIK3CA<\/em>-Mutated Advanced Breast Cancer. NEJM. 2024;391(17):1584-96.<br \/>[9] Juric D, et al. A phase I\/Ib study of inavolisib (GDC-0077) in combination with fulvestrant in patients (pts) with <em>PIK3CA<\/em>-mutated hormone receptor-positive\/HER2-negative (HR+\/HER2\u2013) metastatic breast cancer. Presented at San Antonio Breast Cancer Symposium, 2020 December 7-10; San Antonio, USA. Abstract #P5-17-05.<br \/>[10] Hong R, et al. GDC-0077 is a selective PI3K alpha inhibitor that demonstrates robust efficacy in<em> PIK3CA<\/em> mutant breast cancer models as a single agent and in combination with standard of care therapies. Cancer Res. 2018;78(4):4-14.<br \/>[11] National Cancer Institute: Surveillance, Epidemiology and Ends Result Program. Cancer Stat Facts: Female Breast Cancer Subtypes [Internet; cited 2025 May]. Available from: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pyTPcqPv43fzbQVTKw28tpRFm-MkoDzBJoavwnYrYm2_RK0-5Irk_pTwC9nYHl7bsMgRuZ2M32UuRb-cA10Nrz1U_DcMyUohddtzcJ4NWN_g9x9pNDib9gfedOQ9ujgEoPPoAhnYDSkEEC6m2pR5WaFG6dEquupJDiyLXC5Q3ZUDQLWnu1N7jtWIOFAv2fQaMeyK7aBwSd3YhC6Ohey0pQ==\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/seer.cancer.gov\/statfacts\/html\/breast-subtypes.html<\/a>.\u00a0<br \/>[12] Lim E, et al. The natural history of hormone receptor-positive breast cancer. Oncology (Williston Park). 2012;26(8):688-94,696.<br \/>[13] Tomas R and Barrios CH. Optimal management of hormone receptor positive metastatic breast cancer in 2016. Ther Adv Med Oncol. 2015;7(6):304-20.<br \/>[14] Galipeau N, et al. Understanding key symptoms, side effects, and impacts of HR+\/HER- advanced breast cancer: qualitative study findings. J Patient-Rep Outcomes. 2019;3(1):10.<\/p>\n<p><strong>Roche Global Media Relations<\/strong><strong><br \/><\/strong>Phone: +41 61 688 8888 \/ e-mail: media.relations@roche.com<\/p>\n<table style=\"border-collapse: collapse; width:592px; border-collapse:collapse ;\">\n<tr>\n<td style=\"width:296px;;vertical-align: top ; \">  <strong>Hans Trees, PhD<\/strong><br \/>Phone: +41 79 407 72 58  <\/td>\n<td style=\"width:296px;;vertical-align: top ; \">  <strong>Sileia Urech<\/strong><br \/>Phone: +41 79 935 81 48<\/p>\n<p>\u00a0  <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width:296px;;vertical-align: top ; \">  <strong>Nathalie Altermatt<\/strong><br \/>Phone: +41 79 771 05 25  <\/td>\n<td style=\"width:296px;;vertical-align: top ; \">  <strong>Lorena Corfas<\/strong><br \/>Phone: +41 79 568 24 95<\/p>\n<p>\u00a0  <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width:296px;;vertical-align: top ; \">  <strong>Simon Goldsborough<\/strong><br \/>Phone: +44 797 32 72 915  <\/td>\n<td 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bruno.eschli@roche.com  <\/td>\n<td style=\"width:297px;;vertical-align: top ; \">  <strong>Dr Sabine Borngr\u00e4ber<\/strong><br \/>Phone: +41 61 68-88027<br \/>e-mail: <a href=\"https:\/\/www.globenewswire.com\/news-release\/2025\/05\/31\/3091407\/0\/en\/mailto:sabine.borngraeber@roche.com\" rel=\"nofollow\" target=\"_blank\" title=\"sabine.borngraeber@roche.com\">sabine.borngraeber@roche.com<\/a><\/p>\n<p>\u00a0  <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width:295px;;vertical-align: top ; \">  <strong>Dr Birgit Masjost<\/strong><br \/>Phone: +41 61 68-84814<br \/>e-mail: birgit.masjost@roche.com  <\/td>\n<td style=\"width:297px;;vertical-align: top ; \">  \u00a0  <\/td>\n<\/tr>\n<\/table>\n<p><strong>Investor Relations North America<\/strong><\/p>\n<table style=\"border-collapse: collapse; width:592px; border-collapse:collapse ;\">\n<tr>\n<td style=\"width:298px;;vertical-align: top ; \">  <strong>Loren Kalm<\/strong><br \/>Phone: +1 650 225 3217<br \/>e-mail: kalm.loren@gene.com<\/td>\n<td style=\"width:294px;;vertical-align: top ; \">  \u00a0  <\/td>\n<\/tr>\n<\/table>\n<ul id=\"gnw_attachments_section-items\">\n<li>\n        <a target=\"_blank\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=ZMo2Ya0_9eGPQUKwXg-VX4887wpAmEd29lah7E517BGtslH2kdJEKhattuIkwxmnOKef44kXPn-gLTcWq48W6oIcl5FTXCYz7Suh4N3JdyfItTc3XlkkNdrhWDA2AjMhTzPfupHYjsGaxS3gJrR9wky2b99v_rMOjhaQL0z8IL3gBPLRdQACcq5E0DZR_V9B\" title=\"31052025_INAVO120 study Itovebi_en\" rel=\"nofollow\">31052025_INAVO120 study Itovebi_en<\/a>\n      <\/li>\n<\/ul>\n<p>\n            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>The ItovebiTM (inavolisib)-based regimen reduced the risk of death by more than 30% in people with PIK3CA-mutated HR-positive, HER2-negative advanced breast cancer, compared with palbociclib and fulvestrant alone1 The PIK3CA mutation is found in approximately 40% of HR-positive advanced breast cancers and is associated with a poor prognosis2,3 New data are being presented in an [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":94666,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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