{"id":83846,"date":"2024-08-21T18:29:06","date_gmt":"2024-08-21T18:29:06","guid":{"rendered":"https:\/\/pakistaninewspaperlist.com\/news\/prolynx-announces-preclinical-results-of-long-acting-semaglutide-requiring-once-monthly-dosing\/"},"modified":"2024-08-21T18:29:06","modified_gmt":"2024-08-21T18:29:06","slug":"prolynx-announces-preclinical-results-of-long-acting-semaglutide-requiring-once-monthly-dosing","status":"publish","type":"post","link":"https:\/\/pakistaninewspaperlist.com\/news\/prolynx-announces-preclinical-results-of-long-acting-semaglutide-requiring-once-monthly-dosing\/","title":{"rendered":"ProLynx announces preclinical results of long-acting semaglutide requiring once monthly dosing"},"content":{"rendered":"
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SAN FRANCISCO, Aug. 21, 2024 (GLOBE NEWSWIRE) — ProLynx Inc. today announced the use of their technology to create a long-acting semaglutide that can be administered once monthly. The ProLynx technology involves tethering a therapeutic to hydrogel microspheres via linkers with tunable, pre-programmed release rates. Semaglutide is a peptide GLP-1 agonist that is the active ingredient in the Novo Nordisk blockbuster drugs Ozempic\u00ae<\/sup> and Wegovy\u00ae<\/sup>; Ozempic\u00ae<\/sup> is used to treat Type 2 diabetes, whereas Wegovy\u00ae<\/sup> is a higher-dose version approved for weight loss. Combined sales of these drugs reached about $20 billion in 2023, and demand exceeded supply. Semaglutide has a half-life of about 160 hours and, as with most anti-obesity peptides, must be administered once weekly.<\/p>\n

All peptide drugs have short half-lives and require some form of half-life extension. Almost all of the current anti-obesity drugs, including semaglutide, are “lipidated” peptides \u2013 attached to a fatty acid \u2013 that require once weekly injections. The ProLynx long-acting semaglutide was targeted for once monthly administration, and pharmacokinetic experiments verified an extended half-life of about 30 days in mice. Importantly, a single injection in diet-induced obese mice showed about a 20% weight loss after 30 days, comparable to multiple injections of semaglutide over the same period.<\/p>\n

Daniel Santi, co-founder and President of ProLynx, stated, \u201cOur long-acting semaglutide is compelling because it uses the very same semaglutide that is already approved by the FDA and well-known to patients. The technology simply converts the once weekly drug to one that can be administered once monthly. Previously, ProLynx developed a long-acting monthly peptide GLP-1 agonist as an agent for the treatment of type-2 diabetes (Schneider et al., ACS Chem. Biol. 2017), but this is the first time we achieved this with a lipidated peptide.\u201d<\/p>\n

Using the same approach, ProLynx envisions converting other lipidated peptides of high current interest from once weekly to once monthly administration. Additionally, simulations indicate that the long half-lives and high potencies of some GLP-1 agonists might allow for dosing every three or more months. This could be particularly important in certain patient populations because dosing could coincide with doctor\u2019s visits.<\/p>\n

ProLynx is a San Francisco biotechnology company developing proprietary systems to extend the half-life and improve pharmacokinetics and efficacy, while reducing toxicities of important therapies. ProLynx focuses efforts on areas of unmet needs that its technology can uniquely fill (www.ProLynxinc.com<\/a>). Contact: BD@ProLynxinc.com<\/p>\n

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SAN FRANCISCO, Aug. 21, 2024 (GLOBE NEWSWIRE) — ProLynx Inc. today announced the use of their technology to create a long-acting semaglutide that can be administered once monthly. The ProLynx technology involves tethering a therapeutic to hydrogel microspheres via linkers with tunable, pre-programmed release rates. Semaglutide is a peptide GLP-1 agonist that is the active […]<\/p>\n","protected":false},"author":2,"featured_media":83847,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"fifu_image_url":"https:\/\/ml.globenewswire.com\/Resource\/Download\/4aadd092-3539-454b-ba42-c4c7fb5684c0","fifu_image_alt":"","footnotes":""},"categories":[208],"tags":[],"class_list":["post-83846","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-globenewswire"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t