{"id":68063,"date":"2024-03-06T12:24:04","date_gmt":"2024-03-06T12:24:04","guid":{"rendered":"https:\/\/pakistaninewspaperlist.com\/news\/aslan-pharmaceuticals-announces-new-translational-data-on-eblasakimab-in-copd-and-appoints-leading-respiratory-experts-as-scientific-advisors\/"},"modified":"2024-03-06T12:24:04","modified_gmt":"2024-03-06T12:24:04","slug":"aslan-pharmaceuticals-announces-new-translational-data-on-eblasakimab-in-copd-and-appoints-leading-respiratory-experts-as-scientific-advisors","status":"publish","type":"post","link":"https:\/\/pakistaninewspaperlist.com\/news\/aslan-pharmaceuticals-announces-new-translational-data-on-eblasakimab-in-copd-and-appoints-leading-respiratory-experts-as-scientific-advisors\/","title":{"rendered":"ASLAN Pharmaceuticals Announces New Translational Data on Eblasakimab in COPD and Appoints Leading Respiratory Experts as Scientific Advisors"},"content":{"rendered":"<div id=\"main-body-container\" itemprop=\"articleBody\">\n<ul type=\"disc\">\n<li style=\"margin-bottom:7.9pt;\"><strong>New translational data from a head-to-head study of <\/strong><strong><em>eblasakimab <\/em><\/strong><strong>and <\/strong><strong><em>dupilumab<\/em><\/strong><strong> in a human tissue model of COPD shows <\/strong><strong><em>eblasakimab<\/em><\/strong><strong> performed better than <\/strong><strong><em>dupilumab<\/em><\/strong><strong> in improving airway function and enhancing bronchodilation at the same concentrations<\/strong><\/li>\n<li style=\"margin-bottom:7.9pt;\"><strong>Leading respiratory experts, Ramaswamy Krishnan, PhD, and Reynold Panettieri, MD, appointed as scientific advisors to provide strategic counsel on <\/strong><strong><em>eblasakimab<\/em><\/strong><strong>\u2019s differentiation for future clinical development<\/strong> <strong>in COPD<\/strong><\/li>\n<\/ul>\n<p>SAN MATEO, Calif. and SINGAPORE, March  06, 2024  (GLOBE NEWSWIRE) &#8212; ASLAN Pharmaceuticals Ltd. (Nasdaq: ASLN), a clinical-stage, immunology focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced new positive translational data from a head-to-head study of <em>eblasakimab<\/em> versus <em>dupilumab<\/em> in a human tissue model of chronic obstructive pulmonary disease (COPD) that provides further support for the potential of <em>eblasakimab<\/em> as a biologic therapy for COPD. In addition, the Company announced the appointment of respiratory experts Dr Ramaswamy Krishnan, MS MPhil PhD, Associate Professor in Emergency Medicine, Harvard Medical School, and Dr Reynold Panettieri Jr, MD, Vice Chancellor, Translational Medicine and Science, Rutgers University to ASLAN\u2019s Scientific Advisory Board as it evaluates the potential use of <em>eblasakimab <\/em>as a therapy to treat COPD in addition to atopic dermatitis (AD).<\/p>\n<p>\u201cHaving collaborated with the ASLAN team on the impressive translational data from the head-to-head study of <em>eblasakimab<\/em> and <em>dupilumab <\/em>in COPD patient tissue<em>, <\/em>I am pleased to formally join the Scientific Advisory Board to further explore <em>eblasakimab\u2019s<\/em> potential in COPD,\u201d <strong>said<\/strong> <strong>Dr Ramaswamy Krishnan, MS MPhil PhD, Associate Professor in Emergency Medicine, Harvard Medical School.<\/strong><\/p>\n<p>\u201cI\u2019m delighted to work with the ASLAN team on this exciting opportunity to evaluate development paths for <em>eblasakimab<\/em> in COPD, a Type 2-driven disease. I believe there\u2019s a great opportunity for biologics to transform the treatment landscape for this chronic condition, just as we have observed in the management of other respiratory diseases such as severe asthma. These new data suggest <em>eblasakimab<\/em> has the potential to be a best-in-class biologic treatment for COPD and I look forward to our partnership,\u201d <strong>said<\/strong> <strong>Dr Reynold Panettieri Jr, MD, Vice Chancellor, Translational Medicine and Science, Rutgers University.<\/strong><\/p>\n<p>In November 2023, ASLAN announced translational data from healthy donor tissue that suggested <em>eblasakimab\u2019s<\/em> potential as a COPD therapeutic to inhibit Type 2 inflammation. Further studies have been conducted using lung tissue from a COPD patient, comparing the same concentrations of <em>eblasakimab<\/em> and <em>dupilumab<\/em>. Each treatment condition was tested in at least 6 precision cut lung slices. In the COPD patient tissue, <em>eblasakimab<\/em> was effective in restoring constriction in response to challenges with IL-4 and IL-13, and demonstrated rapid, formoterol-induced airway dilation in constricted airways. Formoterol is a long-acting beta agonist, a class of drugs commonly used by asthmatic and COPD patients to treat their disease. Notably, this preliminary data showed <em>eblasakimab<\/em> performed better than <em>dupilumab<\/em> at the same concentrations in several areas, including the restoration of airway function after challenges with IL-4\u00a0and IL-13.<\/p>\n<p>\u201cWe believe that <em>eblasakimab<\/em> has the potential to be a leading treatment option as we explore its applicability in other diseases besides AD, such as COPD, a large, underserved market with no approved biologics. We look forward to working with Drs Krishnan and Panettieri, and potential partners, to consider potential proof-of-concept Phase 2 study designs in COPD and exploring novel endpoints from recently conducted biologic studies,\u201d<strong> said<\/strong> <strong>Dr Carl Firth, Chief Executive Officer, ASLAN Pharmaceuticals.<\/strong><\/p>\n<p>Further translational data on <em>eblasakimab<\/em> in COPD will be submitted for publication at upcoming scientific congresses.<\/p>\n<p><strong>About Ramaswamy Krishnan, MS MPhil PhD, Associate Professor in Emergency Medicine, Harvard Medical School<\/strong><\/p>\n<p>Ramaswamy Krishnan<strong>, <\/strong>PhD, is an Associate Professor of Emergency Medicine at Harvard Medical School. His laboratory focuses on lung mechanics and mechanotransduction, with an emphasis on how airways contract and relax. To this end, he has invented a suite of technologies to measure airway cell and tissue contraction, relaxation, force transmission, and force transduction. These technologies have not only enabled the discovery of new drug candidates for COPD and asthma in his own laboratory, but are also being utilized worldwide as translational approaches for assessing bronchoprotective and bronchodilatory function of pending candidate medications. Dr Krishnan received his PhD in mechanical engineering from Columbia University and undertook his postdoctoral research in lung physiology at Harvard. He has published over 75 articles, reviews, editorials and chapters, many in renowned peer-reviewed journals including <em>Nature Cell Biology<\/em> and <em>Nature Materials<\/em>.\u00a0<\/p>\n<p><strong>About<\/strong> <strong>Dr Reynold Panettieri Jr, MD Vice Chancellor, Translational Medicine and Science, Rutgers University<\/strong><\/p>\n<p>Reynold A Panettieri Jr, MD, is the inaugural\u00a0Director of the Institute for Translational Medicine and Science\u00a0and Vice Chancellor for Translational Medicine and Science at Rutgers University, having previously served as the Director of the\u00a0Airways Biology Initiative\u00a0at the University of Pennsylvania. Dr Panettieri\u2019s lab focuses on the immunobiology of airway smooth muscle, impact of environmental toxins on airway hyperresponsiveness and identification of novel targets and platforms for therapeutic approaches in asthma and COPD. In addition to his research and clinical interests, Dr Panettieri served as chairperson of the NIH Lung Cellular, Molecular and Immunobiology Study Section, and is a member of the NIH Distinguished Editorial Panel. Dr Panettieri has about 450 publications and undertook his medical training at the University of Pennsylvania.<\/p>\n<p><strong>About<\/strong><strong>\u00a0<\/strong><strong><em>eblasakimab<\/em><\/strong><\/p>\n<p><em>Eblasakimab<\/em> is a potential first-in-class monoclonal antibody targeting the IL-13 receptor subunit of the Type 2 receptor, a key pathway driving several allergic inflammatory diseases. <em>Eblasakimab\u2019s<\/em> unique mechanism of action enables specific blockade of the Type 2 receptor and has the potential to improve upon current biologics used to treat allergic disease. By blocking the Type 2 receptor, <em>eblasakimab<\/em> prevents signaling through both interleukin 4\u00a0(IL-4) and interleukin 13 (IL-13) \u2013 the key drivers of inflammation in AD and Type 2-driven COPD. Positive results from the Phase 2b TREK-AD study in moderate-to-severe AD support <em>eblasakimab\u2019s<\/em> potential to deliver a monthly dosing regimen from initiation in AD without compromising on efficacy and with an encouraging safety profile demonstrated to date, with preparations for Phase 3 underway. ASLAN is also investigating <em>eblasakimab<\/em> in <em>dupilumab<\/em>-experienced, moderate-to-severe AD patients in the Phase 2 trial, TREK-DX.\u00a0\u00a0\u00a0<\/p>\n<p><strong>About ASLAN Pharmaceuticals<\/strong><\/p>\n<p>ASLAN Pharmaceuticals (Nasdaq: ASLN) is a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients. ASLAN is developing\u00a0<em>eblasakimab<\/em>, a potential first-in-class antibody targeting the IL-13 receptor in moderate-to-severe atopic dermatitis (AD) with the potential to improve upon current biologics used to treat allergic disease, and has reported positive topline data from a Phase 2b dose-ranging study in moderate-to-severe AD patients. ASLAN is also developing\u00a0<em>farudodstat<\/em>, a potent oral inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH) as a potential first-in-class treatment for alopecia areata (AA) in a Phase 2a, proof-of-concept trial with an interim readout expected in mid-2024. ASLAN has teams in San Mateo, California, and in Singapore. For additional information please visit the\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=HIjgKB39adTnEYpeq7bnJdXECbfcipBHKliKgELfMZf9Jvj-JuuQuf2CIfFrgesi9Pn8ugZGuaErFYJBKapp-Veppg7X_BkCLGAQfR2gDrc=\" rel=\"nofollow noopener\" target=\"_blank\" title=\"ASLAN website\">ASLAN website<\/a>\u00a0or follow ASLAN on\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=HZIiIKDpAeItxNMgFXqbPCCCviUToIylJ1gy5Ws-1I9L1QAMeGk8rasmTifop-gvpRz7zFUtp5PNrGO7AFASxbYNN5Rh8-zfh8iKtnjoC6gfy_FlfE321yTFWAR9GxNg\" rel=\"nofollow noopener\" target=\"_blank\" title=\"LinkedIn\">LinkedIn<\/a>.<\/p>\n<p><strong>Forward-looking statements <\/strong><\/p>\n<p>This release contains forward-looking statements. These statements are based on the current beliefs and expectations of the management of ASLAN Pharmaceuticals Limited and\/or its affiliates (the &#8220;Company&#8221;). These forward-looking statements may include, but are not limited to statements regarding the Company\u2019s business strategy and clinical development plans; the Company\u2019s plans to develop and commercialize <em>eblasakimab<\/em> and <em>farudodstat<\/em>; the safety and efficacy of <em>eblasakimab<\/em> and <em>farudodstat<\/em>; the Company\u2019s plans and expected timing with respect to manufacturing activities, clinical trials, clinical trial enrolment and clinical trial results for <em>eblasakimab<\/em> and <em>farudodstat<\/em>; the potential of <em>eblasakimab<\/em> as a first-in-class treatment for atopic dermatitis and of farudodstat as a first-in-class treatment for alopecia areata; the potential benefits, capabilities and results of the Company\u2019s collaboration efforts; and the Company\u2019s cash runway. The Company\u2019s estimates, projections and other forward-looking statements are based on management&#8217;s current assumptions and expectations of future events and trends, which affect or may affect the Company\u2019s business, strategy, operations, or financial performance, and inherently involve significant known and unknown risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of many risks and uncertainties, which include, unexpected safety or efficacy data observed during preclinical or clinical studies; the fact that results of earlier studies and trials may not be predictive of future trial results; clinical site activation rates or clinical trial enrolment rates that are lower than expected; the impact of the COVID-19 pandemic, the ongoing conflict between Ukraine and Russia and bank failures on the Company\u2019s business and the global economy; general market conditions; changes in the competitive landscape; and the Company\u2019s ability to obtain sufficient financing to fund its strategic and clinical development plans. Other factors that may cause actual results to differ from those expressed or implied in such forward-looking statements are described in the Company\u2019s US Securities and Exchange Commission filings and reports (Commission File No. 001- 38475), including the Company\u2019s Annual Report on Form 20-F filed with the US Securities and Exchange Commission on March 24, 2023. All statements other than statements of historical fact are forward-looking statements. The words \u201cbelieve,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201ccould,\u201d \u201cwill,\u201d \u201caim,\u201d \u201cestimate,\u201d \u201ccontinue,\u201d \u201canticipate,\u201d \u201cintend,\u201d \u201cexpect,\u201d \u201cplan,\u201d or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes are intended to identify estimates, projections, and other forward-looking statements. Estimates, projections, and other forward-looking statements speak only as of the date they were made, and, except to the extent required by law, the Company undertakes no obligation to update or review any estimate, projection, or forward-looking statement.<\/p>\n<p><strong>Media and IR contacts<\/strong><\/p>\n<p>\n            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>New translational data from a head-to-head study of eblasakimab and dupilumab in a human tissue model of COPD shows eblasakimab performed better than dupilumab in improving airway function and enhancing bronchodilation at the same concentrations Leading respiratory experts, Ramaswamy Krishnan, PhD, and Reynold Panettieri, MD, appointed as scientific advisors to provide strategic counsel on eblasakimab\u2019s 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