{"id":102113,"date":"2025-12-05T10:12:05","date_gmt":"2025-12-05T10:12:05","guid":{"rendered":"https:\/\/pakistaninewspaperlist.com\/news\/imcheck-announces-oral-presentation-of-ict01-first-line-aml-data-at-the-67th-ash-annual-meeting\/"},"modified":"2025-12-05T10:12:05","modified_gmt":"2025-12-05T10:12:05","slug":"imcheck-announces-oral-presentation-of-ict01-first-line-aml-data-at-the-67th-ash-annual-meeting","status":"publish","type":"post","link":"https:\/\/pakistaninewspaperlist.com\/news\/imcheck-announces-oral-presentation-of-ict01-first-line-aml-data-at-the-67th-ash-annual-meeting\/","title":{"rendered":"ImCheck Announces Oral Presentation of ICT01 First-Line AML Data at the 67th ASH Annual Meeting"},"content":{"rendered":"<div id=\"main-body-container\" itemprop=\"articleBody\">\n<p align=\"center\"><strong>ImCheck Announces Oral Presentation of ICT01 First-Line AML Data at the 67th ASH Annual Meeting<\/strong><\/p>\n<p align=\"justify\"><strong>Marseille, France, December 5, 2025 05:00 a.m. ET \/ 11:00 a.m. CET\u2013 <\/strong><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ORWVPtGa0cqfdacB1jbDFIimhkpArTrSmWoL436gIHnqc5CsIazdNVK4s4fpkW2D2BCM1n9Jyr3FKd_0ZTuRNKteplyery2dsQhTpJO8t2WDYYUhYfSebBeC9N-Lxtmr\" rel=\"nofollow\" target=\"_blank\" title=\"ImCheck Therapeutics\">ImCheck Therapeutics<\/a> announced today an oral presentation at the upcoming <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=5tN7bgnCrHckg6mbS8PvHXYrCaI_bSJau2kP7aF1MZDMF-Ooql7JKcd3v9Z0niGKojLrMd156oL8YQgkuDOZS0D_yOyd-8YYnwoqP_KDUKLTXfkVX1zFAVWD7DctXQk93UBuXMJrRkz7fgSAy3P1lh6jzv1-rO0TVRKwboJdiFSaBzL3wh0cHPm-dKK_6FZ0\" rel=\"nofollow\" target=\"_blank\" title=\"\u00a0American Society of Hematology (ASH) Annual Meeting 2025\">\u00a0American Society of Hematology (ASH) Annual Meeting 2025<\/a>, taking place from December 6 to December 9, in <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=vxwFxKY5cnZotjJVGtgCLdZfvCNB1pMELdSIhjtZQl9N0Ws1QWnHZDomwcfGqfrDoaDYE7fchAGe-V6RCB41Lk1_5DjfjfmycT0sUnrcpRnqvoY4LOVuFEPO6LXnSxQafZTJOHKREiejmTM7N0mnV793FPSQq6pX0Hq8nVm7T6vH_JjPSiGv178H_LGgWwOyNHPk2rt50Ma6SCvfBpnMlA1k5v7pFuLmDpPzpeyuvIiIaNkCcmgI1MTaxXB2Bv_kM_HJjm877qqD32Irmo2I4XsC4wO2PunLWEV8vsC6YyiloTNI0iE-E3cDUnwqRd6JbPehbP9rgx52u9lnSt8cidtKa6R46PrYX1yGfNRuLgP2870OwARLfDI1cG1xUupaDSh8xwr1TlT7Q4f_fsMTnaE5VSgARLZ4zPFo_TU-qbEaZ9piN0wWuAuavpg20mSGgQF3XbY1DspfcreByzAVHw==\" rel=\"nofollow\" target=\"_blank\" title=\"Orlando, FL, USA\">Orlando, FL, USA<\/a>. The presentation will highlight the high remission rates and overall survival observed in EVICTION, ImCheck\u2019s open-label, randomized Phase I\/II study evaluating ICT01, a first-in-class \u03b39\u03b42 T-cell activator, in combination with azacitidine and venetoclax in older or unfit patients with newly diagnosed acute myeloid leukemia (AML).<\/p>\n<p align=\"justify\"><strong>Details of the oral presentation at ASH 2025 are:<\/strong><\/p>\n<ul>\n<li><strong>Abstract Title: <\/strong>\u201c\u03b39\u03b42 T-cell (\u03b39\u03b42TC) activation with ICT01 and azacitidine-venetoclax (Aza-Ven) induces high rates of remission and overall survival in patients with newly diagnosed (ND) acute myeloid leukemia (AML): Results from the phase 1\/2 study eviction\u201d<\/li>\n<li><strong>Presenter:<\/strong> Sylvain GRACIAZ, MD, PhD, Institut Paoli-Calmettes, Marseille, France<\/li>\n<li><strong>Session: <\/strong>616. Acute Myeloid Leukemias: Investigational Drug and Cellular Therapies: Immunotherapy and chemotherapy combinations in AML<\/li>\n<li><strong>Room<\/strong>: OCCC &#8211; Chapin Theater (320)<\/li>\n<li><strong>Date: <\/strong>Sunday, December 7, 2025<\/li>\n<li><strong>Time:<\/strong> 5:15 p.m.- 5:30 p.m. ET<\/li>\n<\/ul>\n<p align=\"justify\">The ASH presentation will be available on ImCheck\u2019s corporate website after the presentation has been held.<\/p>\n<p align=\"center\">***<\/p>\n<p><strong>About the EVICTION Study<\/strong><\/p>\n<p align=\"justify\">EVICTION is a first-in-human, dose-escalation (Part\u00a01) and cohort-expansion (Part\u00a02) clinical study of ICT01 in patients with various advanced relapsed or refractory solid or hematologic cancers that have exhausted standard-of-care treatment options. Part\u00a01 (Phase\u00a0I) is designed to characterize the preliminary safety, tolerability, and pharmacodynamic activity of increasing doses of ICT01 as monotherapy (Group\u00a0A: solid tumors; Group\u00a0B: hematologic tumors) and in combination with pembrolizumab (Group\u00a0C: solid tumors). Part\u00a02 comprises randomized dose-optimizing and efficacy estimating expansion cohorts of monotherapy (Group D: ovarian cancer; Group E: prostate cancer) and combination treatment of patients with AML (Group F), melanoma (Group G), urothelial cell carcinoma (Group H), or head-and-neck squamous cell carcinoma (Group I). More information on the\u00a0EVICTION study can be found at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=tzzmXMuYEf30JMdwLaACis1m9c0Z92I7TDs34c66NXjLm_wtBvEBw0jhfCWsM7lt-ZqOmJUborMomm2z6xJRwP766Zd5_E7lwesCMA-tu99fIFlw_TDIqx1ebugJG3Y5ednJr07yEzYnpzKQpqHz5g==\" rel=\"nofollow\" target=\"_blank\" title=\"clinicaltrials.gov\">clinicaltrials.gov<\/a> (NCT04243499).<\/p>\n<p><strong>About ICT01<\/strong><\/p>\n<p align=\"justify\">ICT01 is a humanized, anti-BTN3A (also known as CD277) monoclonal antibody that selectively activates \u03b39\u03b42\u00a0T\u00a0cells, which are responsible for immunosurveillance of malignancy and infections. The three isoforms of BTN3A targeted by ICT01 are overexpressed on many solid tumors (e.g., melanoma, urothelial cell, colorectal, ovarian, pancreatic, and lung cancer) and hematologic malignancies (e.g., leukemia and lymphomas) and also expressed on the surface of innate (e.g., \u03b3\u03b4\u00a0T cells and NK cells) and adaptive immune cells (T\u00a0cells and B\u00a0cells). BTN3A is essential for the activation of the anti-tumor immune response of \u03b39\u03b42 T cells.<\/p>\n<p align=\"justify\">As demonstrated by data presented at past AACR, ASCO, ASH, ESMO and SITC conferences, ICT01 selectively activates circulating \u03b39\u03b42\u00a0T\u00a0cells leading to migration of \u03b39\u03b42\u00a0T\u00a0cells out of the circulation and into the tumor tissue and triggers a downstream immunological cascade through secretion of pro-inflammatory cytokines, including but not limited to IFN\u03b3 and TNF\u03b1, further augmenting the anti-tumor immune response. Anti-tumor activity and efficacy of ICT01 have been shown in patients across several cancer indications.<\/p>\n<p align=\"justify\"><strong>About IMCHECK THERAPEUTICS<\/strong><\/p>\n<p align=\"justify\">ImCheck Therapeutics is developing a new generation of immunotherapeutic antibodies targeting butyrophilins, a novel superfamily of immunomodulators. By unlocking the power of \u03b39\u03b42 T cells, ImCheck\u2019s innovative approach has the potential to transform treatments across oncology, autoimmune, and infectious diseases.<\/p>\n<p align=\"justify\">The lead clinical-stage program, ICT01, has been advancing to late-stage trials, demonstrating a unique mechanism of action that modulates both innate and adaptive immunity. These \u201cfirst-in-class\u201d activating antibodies may deliver superior clinical outcomes compared to first-generation immunotherapy approaches, in particular in rationale combinations with immune checkpoint inhibitors and immunomodulatory anti-cancer drugs. Additionally, ImCheck\u2019s pipeline compounds are progressing toward clinical development for autoimmune and infectious diseases.<br \/>The company benefits from the pioneering research of Prof. Daniel Olive (INSERM, CNRS, Institut Paoli Calmettes, Aix-Marseille University), a global leader in \u03b39\u03b42 T cells and butyrophilins, as well as the expertise of a seasoned management team and the commitment of leading U.S. and European investors. As announced on October 22, Ipsen (Euronext: IPN; ADR: IPSEY) and ImCheck have entered into a definitive share purchase agreement in which Ipsen will acquire all issued and outstanding shares of ImCheck, with the transaction close anticipated by the end of Q1 2026.<\/p>\n<p align=\"justify\"><strong>For further information: <\/strong><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=0EKY60qnnoWT8iZIkazDDmTa8FmRoMH8gLbvGDavlTKLmXD0603E_ulPBIHgAX8Je-IPL1cUFnuCLo1JZBPbfFLg-pdNRmamX0Q_o4vQ8A36vJGWDcRftKmubywgVvVYYSqYza4u7gc-rZrl7Y8PYg==\" rel=\"nofollow\" target=\"_blank\" title=\"\"><strong>https:\/\/www.imchecktherapeutics.com\/<\/strong><\/a><\/p>\n<p><strong>Press contacts: <\/strong><\/p>\n<p align=\"justify\"><strong><u>US and EU <\/u><\/strong><br \/><strong>Trophic Communications<\/strong><br \/>Gretchen Schweitzer <br \/>+49 (0) 172 861 8540<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JmkJoMfA_Ss00reDyfvG2LN447UOIskam0nj7C8KIcCGcxRVWQ2OVsqMVCwYnq6pXUfMqZfRvO4vX7WYWmRb1hlazKUHSblTvg6wJVRDTgY=\" rel=\"nofollow\" target=\"_blank\" title=\"imcheck@trophic.eu\">imcheck@trophic.eu<\/a> <br \/><strong><u>France<\/u><\/strong><br \/><strong>ATCG PARTNERS<\/strong><br \/>C\u00e9line Voisin<br \/>+33 (0)6 62 12 53 39<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JmkJoMfA_Ss00reDyfvG2BNq46AJgnN0dSnh9ZfOUptGMaaDxp_rqnMi2tq8gramdb_4ux6HdkqSkSKv2p3kf7o3wduQ93XmLtIcsjCEEeiSvnSkb4cjbyzjUCjwgSga\" rel=\"nofollow\" target=\"_blank\" title=\"imcheck@atcg-partners.com\">imcheck@atcg-partners.com<\/a><\/p>\n<p>\n            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>ImCheck Announces Oral Presentation of ICT01 First-Line AML Data at the 67th ASH Annual Meeting Marseille, France, December 5, 2025 05:00 a.m. ET \/ 11:00 a.m. CET\u2013 ImCheck Therapeutics announced today an oral presentation at the upcoming \u00a0American Society of Hematology (ASH) Annual Meeting 2025, taking place from December 6 to December 9, in Orlando, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":102114,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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